Gilead Announces 48-Week Data Evaluating Switching From Combivir(R) To Truvada(R) Among Virologically-Suppressed HIV Patients Part 2

Limb tubby be measured using DEXA scan inside a subset of 100 be trained participant, of whom 74 personal both baseline and 48-week facts going spare. In this sub-study, a median reinforcement in appendage fat of 0.21 kg was observed among patients who switch to Truvada and a median reduction of 0.14 kg was observed among patients who lasting subsequent to Combivir (p=0.025). Differences in limb fat be more pronounced among patients who had smaller quantity feel near AZT (zidovudine).

At week 48, a median increase in hemoglobin of 0.5 g/dL was observed among Truvada patients and a median decrease of 0.1 g/dL was observed among those taking Combivir (p<0.001).

Twenty-two percent of patients who switched to Truvada (n=22) experienced an increase in hemoglobin greater than 1 g/dL at 48 weeks compare to 2 percent of Combivir patients (n=2).

Conversely, 9 percent of patients who remain on Combivir (n=8) experienced a cut rate in hemoglobin greater than 1 g/dL, compared to 2 percent of patients who switched to Truvada (n=2).

Truvada patients in the study also experienced improvements across a mixture of lipid parameter. After 48 weeks of rehabilitation, fast whole cholesterol fell through a median of 0.22 mmol/L (8.46 mg/dl) among Truvada patients, compared to a reduction of 0.06 mmol/L (2.30 mg/dl) among Combivir patients (p=0.23; Truvada vs. Combivir comparison). Fasting triglycerides fell by a median of 0.17 mmol/L (15.45 mg/dl) among Truvada patients, but increased by 0.04 mmol/L (3.63 mg/dl) among those who continued treatment with Combivir (p=0.11; Truvada vs. Combivir comparison).

In amalgamation to Zubieta and Scott, the study's playwright are Christian Stohler, DMD, formerly of the U-M School of Dentistry and presently dean of the University of Maryland School of Dentistry; Christine Egnatuk and Heng Wang of the U-M MBNI; and Robert Koeppe, Ph.D., chief of the PET Physics Section in the Nuclear Medicine polarization of the U-M Department of Radiology. The become talented at was fund by the National Institutes of Health.